human NDUFA5 shRNA silencing AAV

Cat. No: shAAV-216482

Availability: 4-5 weeks

Name: AAV-h-NDUFA5-shRNA

This is an AAV expressing shRNA for silencing of Human NDUFA5.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NDUFA5
Gene Name: NADH:ubiquinone oxidoreductase subunit A5
Gene ID: 4698
Gene Synonyms: B13; CI-13kB; CI-13KD-B; NUFM; UQOR13
ORF Size: 351 bp
RefSeq#: NM_005000
Gene Description: The human NDUFA5 gene codes for the B13 subunit of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. The high degree of conservation of NDUFA5 extending to plants and fungi indicates its functional significance in the enzyme complex. The protein localizes to the inner mitochondrial membrane as part of the 7 component-containing, water soluble 'iron-sulfur protein' (IP) fraction of complex I, although its specific role is unknown. It is assumed to undergo post-translational removal of the initiator methionine and N-acetylation of the next amino acid. The predicted secondary structure is primarily alpha helix, but the carboxy-terminal half of the protein has high potential to adopt a coiled-coil form. The amino-terminal part contains a putative beta sheet rich in hydrophobic amino acids that may serve as mitochondrial import signal. Related pseudogenes have also been identified on four other chromosomes.
UniGene ID: Hs.651219
HGNC ID: HGNC:7688