human CXCL11 shRNA silencing AAV

Cat. No: shAAV-206328

Availability: 6-8 weeks

Name: AAV-h-CXCL11-shRNA

This is an AAV expressing shRNA for silencing of Human CXCL11.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CXCL11
Gene Name: C-X-C motif chemokine ligand 11
Gene ID: 6373
Gene Synonyms: b-R1; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B
ORF Size: 285 bp
RefSeq#: NM_005409
Gene Description: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene.
UniGene ID: Hs.632592
HGNC ID: HGNC:10638