human PPM1A shRNA silencing AAV

Cat. No: shAAV-219571

Availability: 4-5 weeks

Name: AAV-h-PPM1A-shRNA

This is an AAV expressing shRNA for silencing of Human PPM1A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PPM1A
Gene Name: protein phosphatase, Mg2+/Mn2+ dependent 1A
Gene ID: 5494
Gene Synonyms: PP2C-ALPHA; PP2CA; PP2Calpha
ORF Size: 1149 bp
RefSeq#: NM_021003
Gene Description: PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
UniGene ID: Hs.130036
HGNC ID: HGNC:9275