human SLC29A1 shRNA silencing AAV

Cat. No: shAAV-223326

Availability: 6-8 weeks

Name: AAV-h-SLC29A1-shRNA

This is an AAV expressing shRNA for silencing of Human SLC29A1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SLC29A1
Gene Name: solute carrier family 29 member 1 (Augustine blood group)
Gene ID: 2030
Gene Synonyms: ENT1
ORF Size: 1371 bp
RefSeq#: NM_004955
Gene Description: SLC29A1 is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
UniGene ID: Hs.25450
HGNC ID: HGNC:11003