human NAB2 shRNA silencing AAV

Cat. No: shAAV-216278

Availability: 6-8 weeks

Name: AAV-h-NAB2-shRNA

This is an AAV expressing shRNA for silencing of Human NAB2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NAB2
Gene Name: NGFI-A binding protein 2
Gene ID: 4665
Gene Synonyms: MADER
ORF Size: 1578 bp
RefSeq#: NM_005967
Gene Description: NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
UniGene ID: Hs.159223
HGNC ID: HGNC:7627