human RNASEH2B shRNA silencing AAV

Cat. No: shAAV-221307

Availability: 6-8 weeks

Name: AAV-h-RNASEH2B-shRNA

This is an AAV expressing shRNA for silencing of Human RNASEH2B.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RNASEH2B
Gene Name: ribonuclease H2 subunit B
Gene ID: 79621
Gene Synonyms: AGS2; DLEU8
ORF Size: 996 bp
RefSeq#: NM_024570
Gene Description: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).
UniGene ID: Hs.306291
HGNC ID: HGNC:25671