human IBSP shRNA silencing AAV

Cat. No: shAAV-211740

Availability: 6-8 weeks

Name: AAV-h-IBSP-shRNA

This is an AAV expressing shRNA for silencing of Human IBSP.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IBSP
Gene Name: integrin binding sialoprotein
Gene ID: 3381
Gene Synonyms: BNSP; BSP; BSP-II; SP-II
ORF Size: 951 bp
RefSeq#: NM_004967
Gene Description: IBSP is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
UniGene ID: Hs.518726
HGNC ID: HGNC:5341