human ATP2A1 shRNA silencing AAV

Cat. No: shAAV-201691

Availability: 6-8 weeks

Name: AAV-h-ATP2A1-shRNA

This is an AAV expressing shRNA for silencing of Human ATP2A1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ATP2A1
Gene Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Gene ID: 487
Gene Synonyms: ATP2A; SERCA1
ORF Size: 3003 bp
RefSeq#: NM_004320
Gene Description: ATP2A1 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.
UniGene ID: Hs.657344
HGNC ID: HGNC:811