human VHL shRNA silencing AAV

Cat. No: shAAV-227474

Availability: 4-5 weeks

Name: AAV-h-VHL-shRNA

This is an AAV expressing shRNA for silencing of Human VHL.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: VHL
Gene Name: von Hippel-Lindau tumor suppressor
Gene ID: 7428
Gene Synonyms: HRCA1; pVHL; RCA1; VHL1
ORF Size: 519 bp
RefSeq#: NM_000551
Gene Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
UniGene ID: Hs.517792
HGNC ID: HGNC:12687