human RAD18 shRNA silencing AAV

Cat. No: shAAV-220635

Availability: 4-5 weeks

Name: AAV-h-RAD18-shRNA

This is an AAV expressing shRNA for silencing of Human RAD18.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RAD18
Gene Name: RAD18, E3 ubiquitin protein ligase
Gene ID: 56852
Gene Synonyms: RNF73
ORF Size: 1488 bp
RefSeq#: NM_020165
Gene Description: RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
UniGene ID: Hs.375684
HGNC ID: HGNC:18278