human PRF1 shRNA silencing AAV

Cat. No: shAAV-219811

Availability: 6-8 weeks

Name: AAV-h-PRF1-shRNA

This is an AAV expressing shRNA for silencing of Human PRF1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PRF1
Gene Name: perforin 1
Gene ID: 5551
Gene Synonyms: FLH2; HPLH2; P1; PFN1; PFP
ORF Size: 1668 bp
RefSeq#: NM_005041
Gene Description: PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
UniGene ID: Hs.2200
HGNC ID: HGNC:9360