human BPGM shRNA silencing AAV

Cat. No: shAAV-202237

Availability: 4-5 weeks

Name: AAV-h-BPGM-shRNA

This is an AAV expressing shRNA for silencing of Human BPGM.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BPGM
Gene Name: bisphosphoglycerate mutase
Gene ID: 669
Gene Synonyms: DPGM
ORF Size: 780 bp
RefSeq#: NM_001724
Gene Description: 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.
UniGene ID: Hs.198365
HGNC ID: HGNC:1093