human OTUB1 shRNA silencing AAV

Cat. No: shAAV-217996

Availability: 4-5 weeks

Name: AAV-h-OTUB1-shRNA

This is an AAV expressing shRNA for silencing of Human OTUB1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: OTUB1
Gene Name: OTU deubiquitinase, ubiquitin aldehyde binding 1
Gene ID: 55611
Gene Synonyms: HSPC263; OTB1; OTU1
ORF Size: 816 bp
RefSeq#: NM_017670
Gene Description: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
UniGene ID: Hs.473788
HGNC ID: HGNC:23077