mouse MTM1 shRNA silencing AAV

Cat. No: shAAV-265145

Availability: 4-5 weeks

Name: AAV-m-MTM1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mtm1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mtm1
Gene Name: X-linked myotubular myopathy gene 1
Gene ID: 17772
Gene Synonyms: AF073996; mKIAA4176; Mtm
ORF Size: 1812 bp
RefSeq#: NM_019926
Gene Description: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.
UniGene ID: Mm.423278