mouse UNC5B shRNA silencing AAV

Cat. No: shAAV-275637

Availability: 6-8 weeks

Name: AAV-m-UNC5B-shRNA

This is an AAV expressing shRNA for silencing of Mouse Unc5b.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Unc5b
Gene Name: unc-5 netrin receptor B
Gene ID: 107449
Gene Synonyms: 6330415E02Rik; A630020F16; D10Bwg0792e; Unc5h2
ORF Size: 2805 bp
RefSeq#: NM_029770
Gene Description: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
UniGene ID: Mm.290433