human TPH2 shRNA silencing AAV

Cat. No: shAAV-226258

Availability: 6-8 weeks

Name: AAV-h-TPH2-shRNA

This is an AAV expressing shRNA for silencing of Human TPH2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TPH2
Gene Name: tryptophan hydroxylase 2
Gene ID: 121278
Gene Synonyms: ADHD7; NTPH
ORF Size: 1491 bp
RefSeq#: NM_173353
Gene Description: TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. TPH2 is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
UniGene ID: Hs.376337
HGNC ID: HGNC:20692