human KDSR shRNA silencing AAV

Cat. No: shAAV-212863

Availability: 4-5 weeks

Name: AAV-h-KDSR-shRNA

This is an AAV expressing shRNA for silencing of Human KDSR.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: KDSR
Gene Name: 3-ketodihydrosphingosine reductase
Gene ID: 2531
Gene Synonyms: DHSR; FVT1; SDR35C1
ORF Size: 999 bp
RefSeq#: NM_002035
Gene Description: KDSR catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.
UniGene ID: Hs.74050
HGNC ID: HGNC:4021