human MAPK10 shRNA silencing AAV

Cat. No: shAAV-214967

Availability: 4-5 weeks

Name: AAV-h-MAPK10-shRNA

This is an AAV expressing shRNA for silencing of Human MAPK10.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MAPK10
Gene Name: mitogen-activated protein kinase 10
Gene ID: 5602
Gene Synonyms: JNK3; JNK3A; p493F12; p54bSAPK; PRKM10; SAPK1b
ORF Size: 1395 bp
RefSeq#: NM_002753
Gene Description: MAPK10 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniGene ID: Hs.125503
HGNC ID: HGNC:6872