human NSUN2 shRNA silencing AAV

Cat. No: shAAV-217119

Availability: 4-5 weeks

Name: AAV-h-NSUN2-shRNA

This is an AAV expressing shRNA for silencing of Human NSUN2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NSUN2
Gene Name: NOP2/Sun RNA methyltransferase family member 2
Gene ID: 54888
Gene Synonyms: MISU; MRT5; SAKI; TRM4
ORF Size: 2304 bp
RefSeq#: NM_017755
Gene Description: NSUN2 encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
UniGene ID: Hs.481526
HGNC ID: HGNC:25994