mouse SREBF1 shRNA silencing AAV

Cat. No: shAAV-273127

Availability: 4-5 weeks

Name: AAV-m-SREBF1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Srebf1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Srebf1
Gene Name: sterol regulatory element binding transcription factor 1
Gene ID: 20787
Gene Synonyms: ADD1; bHLHd1; SREBP-1a; SREBP1; SREBP1c
ORF Size: 3405 bp
RefSeq#: NM_011480
Gene Description: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
UniGene ID: Mm.278701