human XRCC3 shRNA silencing AAV

Cat. No: shAAV-231453

Availability: 6-8 weeks

Name: AAV-h-XRCC3-shRNA

This is an AAV expressing shRNA for silencing of Human XRCC3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: XRCC3
Gene Name: X-ray repair cross complementing 3
Gene ID: 7517
Gene Synonyms: CMM6
ORF Size: 1041 bp
RefSeq#: NM_005432
Gene Description: XRCC3 encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
UniGene ID: Hs.719391
HGNC ID: HGNC:12830