human FOXP2 shRNA silencing AAV

Cat. No: shAAV-209279

Availability: 6-8 weeks

Name: AAV-h-FOXP2-shRNA

This is an AAV expressing shRNA for silencing of Human FOXP2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: FOXP2
Gene Name: forkhead box P2
Gene ID: 93986
Gene Synonyms: CAGH44; SPCH1; TNRC10
ORF Size: 2145 bp
RefSeq#: NM_014491
Gene Description: FOXP2 encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. FOXP2 is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
UniGene ID: Hs.656280
HGNC ID: HGNC:13875