human DENND1C shRNA silencing AAV

Cat. No: shAAV-206867

Availability: 6-8 weeks

Name: AAV-h-DENND1C-shRNA

This is an AAV expressing shRNA for silencing of Human DENND1C.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DENND1C
Gene Name: DENN domain containing 1C
Gene ID: 79958
Gene Synonyms: FAM31C
ORF Size: 2406 bp
RefSeq#: NM_024898
Gene Description: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed 20154091)).(supplied by OMIM, Nov 2010)
UniGene ID: Hs.236449
HGNC ID: HGNC:26225