human SARDH shRNA silencing AAV

Cat. No: shAAV-222252

Availability: 6-8 weeks

Name: AAV-h-SARDH-shRNA

This is an AAV expressing shRNA for silencing of Human SARDH.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SARDH
Gene Name: sarcosine dehydrogenase
Gene ID: 1757
Gene Synonyms: BPR-2; DMGDHL1; SAR; SARD; SDH
ORF Size: 2757 bp
RefSeq#: NM_007101
Gene Description: SARDH encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described.
UniGene ID: Hs.198003
HGNC ID: HGNC:10536