human SALL3 shRNA silencing AAV

Cat. No: shAAV-222208

Availability: 6-8 weeks

Name: AAV-h-SALL3-shRNA

This is an AAV expressing shRNA for silencing of Human SALL3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SALL3
Gene Name: spalt like transcription factor 3
Gene ID: 27164
Gene Synonyms: ZNF796
ORF Size: 2880 bp
RefSeq#: NM_171999
Gene Description: SALL3 encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis.
UniGene ID: Hs.700557
HGNC ID: HGNC:10527