mouse LRP6 shRNA silencing AAV

Cat. No: shAAV-263817

Availability: 4-5 weeks

Name: AAV-m-LRP6-shRNA

This is an AAV expressing shRNA for silencing of Mouse Lrp6.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Lrp6
Gene Name: low density lipoprotein receptor-related protein 6
Gene ID: 16974
Gene Synonyms: C030016K15Rik; Cd; Gw; ska26; ska; skax26
ORF Size: 4842 bp
RefSeq#: NM_008514
Gene Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
UniGene ID: Mm.321990