mouse TWIST1 shRNA silencing AAV

Cat. No: shAAV-275367

Availability: 6-8 weeks

Name: AAV-m-TWIST1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Twist1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Twist1
Gene Name: twist basic helix-loop-helix transcription factor 1
Gene ID: 22160
Gene Synonyms: bHLHa38; M-Twist; Pde; pdt; Ska10; Ska; Twist
ORF Size: 621 bp
RefSeq#: NM_011658
Gene Description: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
UniGene ID: Mm.3280