human BRAF shRNA silencing AAV

Cat. No: shAAV-202247

Availability: 4-5 weeks

Name: AAV-h-BRAF-shRNA

This is an AAV expressing shRNA for silencing of Human BRAF.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BRAF
Gene Name: B-Raf proto-oncogene, serine/threonine kinase
Gene ID: 673
Gene Synonyms: B-raf; B-RAF1; BRAF1; NS7; RAFB1
ORF Size: 2301 bp
RefSeq#: NM_004333
Gene Description: BRAF encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
UniGene ID: Hs.550061
HGNC ID: HGNC:1097