human CTNS shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

CTNS

Gene Name

cystinosin, lysosomal cystine transporter

Gene ID

1497

Gene Synonyms

CTNS-LSB; PQLC4

ORF Size

1203 bp

RefSeq#

NM_004937

Gene Description

CTNS encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

UniGene ID

Hs.187667

HGNC ID

HGNC:2518