mouse CASP9 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Casp9

Gene Name

caspase 9

Gene ID

12371

Gene Synonyms

AI115399; APAF-3; AW493809; CASP-9; Caspase-9; ICE-LAP6; Mch6

ORF Size

1365 bp

RefSeq#

NM_015733

Gene Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)|Function: Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

UniGene ID

Mm.468800