mouse PPM1A shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Ppm1a

Gene Name

protein phosphatase 1A, magnesium dependent, alpha isoform

Gene ID

19042

Gene Synonyms

2310003C21Rik; 2900017D14Rik; AI427932; AU017636; MMPa-2; MPPa-1

ORF Size

1149 bp

RefSeq#

NM_008910

Gene Description

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.

UniGene ID

Mm.261045