human ZIC2 shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

ZIC2

Gene Name

Zic family member 2

Gene ID

7546

Gene Synonyms

HPE5

ORF Size

1596 bp

RefSeq#

NM_007129

Gene Description

ZIC2 encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. ZIC2 is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.

UniGene ID

Hs.653700

HGNC ID

HGNC:12873