human DKK1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

DKK1

Gene Name

dickkopf WNT signaling pathway inhibitor 1

Gene ID

22943

Gene Synonyms

DKK-1; SK

ORF Size

801 bp

RefSeq#

NM_012242

Gene Description

DKK1 encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

UniGene ID

Hs.40499

HGNC ID

HGNC:2891