mouse OGT shRNA silencing Adenovirus

Cat. No: shADV-266353

Availability: 3-5 weeks

Name: Ad-m-OGT-shRNA

This is an Adenovirus expressing shRNA for silencing of Mouse Ogt.

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Species: Mouse
Gene Symbol: Ogt
Gene Name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Gene ID: 108155
Gene Synonyms: 1110038P24Rik; 4831420N21Rik; AI115525; Ogtl
ORF Size: 3141 bp
RefSeq#: NM_139144
Gene Description: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues|Function: Isoform 2, the mitochondrial isoform (mOGT), is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line.
UniGene ID: Mm.474838