human OPA1 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

OPA1

Gene Name

OPA1, mitochondrial dynamin like GTPase

Gene ID

4976

Gene Synonyms

BERHS; largeG; MGM1; MTDPS14; NPG; NTG

ORF Size

2883 bp

RefSeq#

NM_130832

Gene Description

OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.594504

HGNC ID

HGNC:8140