human POU2F3 shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

POU2F3

Gene Name

POU class 2 homeobox 3

Gene ID

25833

Gene Synonyms

Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a

ORF Size

1311 bp

RefSeq#

NM_014352

Gene Description

POU2F3 encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniGene ID

Hs.227115

HGNC ID

HGNC:19864