human EGLN2 shRNA silencing AAV

Cat. No: shAAV-207664

Availability: 4-5 weeks

Name: AAV-h-EGLN2-shRNA

This is an AAV expressing shRNA for silencing of Human EGLN2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: EGLN2
Gene Name: egl-9 family hypoxia inducible factor 2
Gene ID: 112398
Gene Synonyms: EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1
ORF Size: 1224 bp
RefSeq#: NM_080732
Gene Description: The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.
UniGene ID: Hs.515417
HGNC ID: HGNC:14660