human CXCL12 shRNA silencing Adenovirus

Product Info

Knockdown

>60% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

CXCL12

Gene Name

C-X-C motif chemokine ligand 12

Gene ID

6387

Gene Synonyms

IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1

ORF Size

270 bp

RefSeq#

NM_000609

Gene Description

CXCL12 encodes a stromal cell-derived alpha chemokine member of the intercrine family. CXCL12 product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.522891

HGNC ID

HGNC:10672