human ACACB shRNA silencing AAV

Cat. No: shAAV-200148

Availability: 4-5 weeks

Name: AAV-h-ACACB-shRNA

This is an AAV expressing shRNA for silencing of Human ACACB.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACACB
Gene Name: acetyl-CoA carboxylase beta
Gene ID: 32
Gene Synonyms: ACC2; ACCB; HACC275
ORF Size: 7377 bp
RefSeq#: NM_001093
Gene Description: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.
UniGene ID: Hs.234898
HGNC ID: HGNC:85