human CBFA2T3 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

CBFA2T3

Gene Name

CBFA2/RUNX1 translocation partner 3

Gene ID

863

Gene Synonyms

ETO2; MTG16; MTGR2; RUNX1T3; ZMYND4

ORF Size

1962 bp

RefSeq#

NM_005187

Gene Description

CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. CBFA2T3 is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

UniGene ID

Hs.513811

HGNC ID

HGNC:1537