human CDK11A shRNA silencing AAV

Cat. No: shAAV-232713

Availability: 4-5 weeks

Name: AAV-h-CDK11A-shRNA

This is an AAV expressing shRNA for silencing of Human CDK11A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CDK11A
Gene Name: cyclin dependent kinase 11A
Gene ID: 728642
Gene Synonyms: CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE
ORF Size: 1194 bp
RefSeq#: NM_024011
Gene Description: CDK11A encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. CDK11A is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. CDK11A and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far.
UniGene ID: Hs.
HGNC ID: HGNC:1730