human CHMP2B shRNA silencing AAV

Cat. No: shAAV-205163

Availability: 4-5 weeks

Name: AAV-h-CHMP2B-shRNA

This is an AAV expressing shRNA for silencing of Human CHMP2B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CHMP2B
Gene Name: charged multivesicular body protein 2B
Gene ID: 25978
Gene Synonyms: ALS17; CHMP2.5; DMT1; VPS2-2; VPS2B
ORF Size: 642 bp
RefSeq#: NM_014043
Gene Description: CHMP2B encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
UniGene ID: Hs.476930
HGNC ID: HGNC:24537