human H2AFZ shRNA silencing AAV

Cat. No: shAAV-210748

Availability: 4-5 weeks

Name: AAV-h-H2AFZ-shRNA

This is an AAV expressing shRNA for silencing of Human H2AFZ.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: H2AFZ
Gene Name: H2A histone family member Z
Gene ID: 3015
Gene Synonyms: H2A.z; H2A.Z-1; H2A/z; H2AZ
ORF Size: 387 bp
RefSeq#: NM_002106
Gene Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
UniGene ID: Hs.119192
HGNC ID: HGNC:4741