human MBNL2 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

MBNL2

Gene Name

muscleblind like splicing regulator 2

Gene ID

10150

Gene Synonyms

MBLL; MBLL39; PRO2032

ORF Size

1086 bp

RefSeq#

NM_207304

Gene Description

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. MBNL2 encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

UniGene ID

Hs.657347

HGNC ID

HGNC:16746