human PRDX3 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PRDX3

Gene Name

peroxiredoxin 3

Gene ID

10935

Gene Synonyms

AOP-1; AOP1; MER5; MGC104387; MGC24293; PRO1748; SP-22;

ORF Size

771 bp

RefSeq#

NM_006793

Gene Description

PRDX3 encodes a protein with antioxidant function and is localized in the mitochondrion. PRDX3 shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.

UniGene ID

Hs.523302

HGNC ID

HGNC:9354