mouse NOS3 shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Nos3

Gene Name

nitric oxide synthase 3, endothelial cell

Gene ID

18127

Gene Synonyms

2310065A03Rik; ecNOS; eNOS; Nos-3

ORF Size

3609 bp

RefSeq#

NM_008713

Gene Description

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets|Function: Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may downregulate eNOS activity by forming heterodimers with isoform 1.

UniGene ID

Mm.258415