human EIF2AK2 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

EIF2AK2

Gene Name

eukaryotic translation initiation factor 2 alpha kinase 2

Gene ID

5610

Gene Synonyms

EIF2AK1; PKR; PPP1R83; PRKR

ORF Size

1656 bp

RefSeq#

NM_002759

Gene Description

EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

UniGene ID

Hs.131431

HGNC ID

HGNC:9437