human HNMT Over-expression AAV

Cat. No: AAV-211331

Availability: 3-5 weeks

Name: AAV-h-HNMT

This is an AAV expressing Human HNMT.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HNMT
Gene Name: histamine N-methyltransferase
Gene ID: 3176
Gene Synonyms: HMT; HNMT-S1; HNMT-S2; MRT51
ORF Size: 879 bp
RefSeq#: BC020677
Gene Description: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
UniGene ID: Hs.42151
HGNC ID: HGNC:5028