human EDNRA shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

EDNRA

Gene Name

endothelin receptor type A

Gene ID

1909

Gene Synonyms

ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA

ORF Size

1284 bp

RefSeq#

NM_001957

Gene Description

EDNRA encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

UniGene ID

Hs.183713

HGNC ID

HGNC:3179