mouse TICAM1 Over-expression AAV

Cat. No: AAV-274195

Availability: 3-5 weeks

Name: AAV-m-TICAM1

This is an AAV expressing Mouse Ticam1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Ticam1
Gene Name: toll-like receptor adaptor molecule 1
Gene ID: 106759
Gene Synonyms: AW046014; AW547018; TICAM-1; TRIF
ORF Size: 2199 bp
RefSeq#: BC094338
Gene Description: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
UniGene ID: Mm.203952